CORRECTION

Transpl. Int., 17 December 2025

Volume 38 - 2025 | https://doi.org/10.3389/ti.2025.15860

Corrigendum: Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality

  • 1. Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany

  • 2. Transplant Immunology Research Center of Excellence TIREX, Koç University School of Medicine, Istanbul, Türkiye

  • 3. Division of Nephrology, Department of Internal Medicine, Yeditepe University School of Medicine, Istanbul, Türkiye

  • 4. Department of Internal Medicine and Nephrology, Faculty of Medicine, Assiut University, Assiut, Egypt

  • 5. Health Sector and Department of Immunology, College of Medicine, Qatar University, Doha, Qatar

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Abstract

Graphical Abstract

High tacrolimus metabolism is linked to increased kidney transplant failure and infection-related mortality. The study analyzed 21,865 kidney transplants from 2000 to 2019, the largest to date. About 25.2% had a low concentration-dose-ratio (CDR), predicting poor outcomes with a hazard ratio up to 2.80 and a 63% increase in infection-related mortality. Higher risk groups include females, young individuals, and those with CYP3A5*1A. Strategies like diltiazem co-medication and steroid tapering may improve long-term outcomes in patients with low CDR. Conducted by Caner Süsal, published in Transplant International.

In the published article, there was an error in the article title. Instead of “Hidden in Plain Sight: Low Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality”, it should be “Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality”.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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Summary

Keywords

kidney transplant, tacrolimus concentration-to-dose ratio, allograft loss, mortality, infection

Citation

Süsal C, Döhler B, Demir E, Ibrahim W and Askar M (2025) Corrigendum: Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality. Transpl. Int. 38:15860. doi: 10.3389/ti.2025.15860

Received

06 November 2025

Revised

06 November 2025

Accepted

24 November 2025

Published

17 December 2025

Volume

38 - 2025

Updates

Copyright

*Correspondence: Caner Süsal, ; Medhat Askar,

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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