Anti-HLA DSA and Beyond: deciphering the immunological mechanisms driving chronic rejection

Despite the progress achieved over the last two decades in the field of therapeutic immunosuppression, immune-mediated destruction of allograft (aka chronic rejection) remains among the first causes of late failure. A better understanding of the mechanisms involved first in allorecognition and then in generating graft damages and allograft fibrosis, appears as a mandatory step to design future innovative therapeutic strategies with the potential to improve long-term outcomes.

This Special Issue of Transplant International gathers the best international experts to propose a synthesis of the latest advances in transplant immunology in the field of chronic rejection immunopathology.


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Keywords: allograft, immunosuppression, allorecognition, allograft fibrosis