Molecular and Biochemical Foundations of Health and Disease

Health and disease arise from tightly regulated molecular and biochemical processes that govern cellular homeostasis, signaling, metabolism, and gene expression. Disruptions at the level of proteins, nucleic acids, metabolites, and regulatory networks underlie the development of a wide spectrum of pathological conditions, ranging from metabolic and cardiovascular disorders to neuropsychiatric and oncological diseases. Advances in molecular biology, biochemistry, and systems-level approaches have significantly deepened our understanding of these mechanisms, revealing complex interactions between genetic, epigenetic, environmental, and metabolic factors.

This Special Issue aims to integrate fundamental and translational perspectives, highlighting research that elucidates molecular pathways, identifies biomarkers, and explores novel therapeutic targets. By bridging mechanistic insights with clinical relevance, the collection seeks to provide a comprehensive overview of how biochemical and molecular foundations shape both physiological resilience and disease vulnerability. Emphasis will be placed on interdisciplinary approaches that connect basic science discoveries with potential diagnostic and therapeutic applications.

This Special Issue welcomes contributions that improve our understanding of the molecular and biochemical foundations underlying health and disease. We aim to gather high-quality studies that elucidate fundamental cellular and metabolic mechanisms, identify biomarkers of physiological and pathological processes, and explore pathways with diagnostic or therapeutic potential. Particular attention will be given to integrative and systems-level approaches that connect molecular insights with clinical relevance, including complex and multifactorial conditions such as metabolic, cardiovascular, neuropsychiatric, oncological, and addiction-related disorders. By fostering interdisciplinary dialogue, this Issue seeks to bridge basic biochemistry with translational and clinical applications..
Potential areas of interest may include, but are not limited to:
● Molecular signaling pathways in physiology and pathophysiology
● Genetic and epigenetic regulation of disease processes
● Biomarker discovery and validation
● Metabolic reprogramming and cellular homeostasis
● Molecular mechanisms underlying addictions and neurobiological disorders
● Translational studies linking biochemical insights to therapeutic strategies

Authors are welcome to submit articles presenting original studies or literature review work. Please consult the journal's information regarding Article Types, Author Guidelines, and Publishing Fees, or direct any questions to the Editorial Office: abp@frontierspartnerships.org.

Even though abstract submission is not mandatory, we encourage all interested researchers to submit a “manuscript summary” before submitting their article. Manuscript summaries do not have to coincide with the final abstract of the article.

Article types and fees

This Special Issue accepts the following article types, unless otherwise specified in the Special Issue description:

• Brief Research Report
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Special Issue accepts the following article types, unless otherwise specified in the Special Issue description:

• Brief Research Report
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review

Keywords: Molecular mechanisms, Biochemical pathways, Health and disease, Biomarkers, Translational research, Addictions