Immunomodulation and oxidative stress as tools for cancer treatment and regenerative medicine

Inflammation is a key response of living, vascularized tissues to injury. Its purpose is to remove infectious agents and other inflammatory triggers and is crucial for repair processes in damaged tissues. Inflammation is a multi-stage process involving multiple mediators that regulate specific aspects of the inflammatory response, according to a well-defined chronobiological program.

Immunometabolism is referred to as the metabolic processes and molecular regulation in the immune system, playing a crucial role in modulating the development, activity, and function of different immune cells. It encompasses various aspects, including energy production, transport of substances, signal transduction, and molecular regulation, which are essential for maintaining immune cell function. Knowledge of these regulatory processes provides a useful tool for promoting healing or use inflammation and oxidative stress to combat cancer cells.

Reactive oxygen and nitrogen species are produced in the organism under both physiological and pathological conditions. Low levels are tolerated by cells and can act as redox transducers in intracellular signaling pathways. There are also wide possibilities for their therapeutic applications, such as tissue disinfection, combating skin infections, promoting healing, and anti-cancer therapies. However, overproduction affects cell function, damaging their structures and leading to cell death by promoting intrinsic apoptotic pathways or tissue injury.

Various factors could modify the inflammatory response, among others bioactive compounds, regulatory and host defense peptides, or oxidative stress modifiers (such as the use of cold atmospheric plasma or ozonation), encompassing numerous clinical aspects in regenerative medicine and oncology. However, knowledge of the molecular mechanisms of these factors' interactions with host immune cells remains incomplete, hindering the assessment of their safety.

This Special Issue welcomes contributions that improve our understanding of the processes involved in regulation of inflammation and oxidative stress in tissue repair and neoplastic disorders. Potential areas of interest may include, but are not limited to:
• Cold atmospheric plasma in biomedical applications
• Host defense and regulatory peptides
• Immunometabolism
• Potential of inflammatory agents and oxidative stress in regenerative medicine
• Target therapy

We encourage the submission of different article types to this collection, especially original research papers, reviews, and mini-reviews.

Authors are welcome to submit articles presenting original studies or literature review work. Please consult the journal's information regarding Article Types, Author Guidelines, and Publishing Fees, or direct any questions to the Editorial Office: abp@frontierspartnerships.org.

Even though abstract submission is not mandatory, we encourage all interested researchers to submit a “manuscript summary” before submitting their article. Manuscript summaries do not have to coincide with the final abstract of the article.

Article types and fees

This Special Issue accepts the following article types, unless otherwise specified in the Special Issue description:

• Brief Research Report
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Special Issue accepts the following article types, unless otherwise specified in the Special Issue description:

• Brief Research Report
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review

Keywords: Inflammation, Immunomodulation, oxidative stress, tissue repair, neoplastic disorders