The p53 protein, often termed as a guardian of genome, is one of the major transcription factors responsible for cell cycle regulation and prevention of cancer development. It has been demonstrated that more than 50-60% of all human tumors are strictly associated with mutations in the TP53 gene which result in the disruption of the p53
networks in the cell and eventually promote survival of the p53-mutated cells and as a consequences, chemoresistance.

Recent works have shown that p53 protein is also involved in metabolism, immune response, autophagy and cell-cell communication. It emerges that p53 has a strong impact on maintaining of cell homeostasis by regulation of the cellular pathways including glycolysis, gluconeogenesis, fatty acids synthesis and storage, nucleotides
synthesis or redox balance. Despite extensive research conducted over years, the role of p53 is not fully understood. There are many questions about p53 protein which are still unanswered.

This Special Issue welcomes contributions which expand our knowledge about the mechanisms of p53 action, p53-mediated networks, interaction of p53 with proteins and noncoding RNAs and mutations in TP53 gene with their consequences for the cell fate.

Potential areas of interest may include, but are not limited to:
● The role of p53 and p53 family in tumor suppression
● Involvement of p53 in metabolism and immune response
● Biochemical and biophysical studies of p53 protein and its mutated versions
● P53 isoforms
● Regulation of the expression of p53 at the transcriptional and translational level

Authors are welcome to submit articles presenting original studies or literature review work. Please consult the journal's information regarding Article Types, Author Guidelines, and Publishing Fees, or direct any questions to the Editorial Office: abp@frontierspartnerships.org.

Even though abstract submission is not mandatory, we encourage all interested researchers to submit a manuscript summary before submitting their manuscript. Manuscript summaries do not have to coincide with the final abstract of the manuscripts.

Articles

Structural potential of the 5′ noncoding regions of the mRNAs encoding p53 isoforms

Acta Biochimica Polonica