Abstract
The expansion of the transplant donor pool, driven by the need to reduce the disparity between supply and demand, carries the risk of use of marginal donors with viral infections, including classic viruses and emerging threats. This narrative review analyzes these challenges, including new opportunities in managing well known viruses such as Hepatitis B, Hepatitis C and Human Immunodeficiency Virus in both donors and recipients, thanks to new effective antivirals. Furthermore, we highlight the importance of monitoring emerging viral pathogens, such as Hepatitis E and Human Herpesvirus 8 (HHV-8) implementing both targeted pre-transplant donor screening and timely post-transplant diagnosis in the recipient, enabling earlier therapeutic intervention and potentially reducing recipient morbidity and mortality. Moreover, respiratory viral infections have gained significant attention as potential causes of donor derived infection (DDI) transmitted to the recipient, particularly within specific widespread and seasonal contexts, and require further attention and investigation. Continuous updates to surveillance and screening protocols are essential to optimize outcomes of recipients, ensuring transplant safety.
Introduction
The number of individuals awaiting transplant continues to overcome donor availability. Several efforts are ongoing to expand the donor pool to include donors at increased infectious risk [, ].
A paradigm shift has occurred in the utilization of organs from HBV- and HCV-positive donors, with increasing acceptance of their use in both infected and uninfected recipients. The opioid epidemic has climbed sharply in specific settings (primarily North America), ascending rates of drug abusers with overdose-related deaths has led to the use of available organs from young donors with limited comorbidities, but with higher risk of transmission of HCV, HBV and Human Immunodeficiency Virus (HIV) [–]. Of interest that a significant increase in mortality waitlist has been described for individuals who decline these marginal organs compared with those who accept the risk reducing wait time [, ].
The potential for donor-derived transmission of previously underestimated viruses (Hepatitis E, Human herpesvirus 8) highlights the importance of surveillance and screening protocols in specific geographical settings [, ]. Respiratory viral infections have received increased attention in recent years, including as a potential cause of donor derived infection (DDI), especially in specific seasonal settings []. The complex and intricate relationship between climate change, human migration, and infectious disease transmission presents a global challenge that can impact the risk of DDI [, ].
The aim of this narrative review is to offer an update on old and new challenges in managing donor derived viral infections. DDI caused by Arboviruses will be discussed in a separate review focused on risk for infectious tropical disease transmission.
Hepatitis C
In the past, organs from HCV positive donors were commonly discarded or restricted to recipients with chronic HCV due to poor outcomes with interferon-based therapy and high risk of transmission to uninfected recipients. The advent of effective direct-acting antivirals (DAA) has led to HCV eradication and a shift toward the use of HCV NAT positive organs. Moreover, interest in using HCV-positive donors has grown in association with the opioid epidemic in specific geographical settings, reflecting a significant expansion of the donor pool [].
The risk of transmission of the virus varies significantly. The transmission rates among all HCV seropositive liver allografts (HCV Ab positive, HCV RNA negative) may be relatively low ranging from 9% to 16% []. HCV viremic donors (HCV Ab positive, HCV RNA positive) transmit HCV almost universally [].
Optimal follow up, DAA regimen and timing of therapy initiation, has not been established and factors such as genotype, renal function, drug-drug interactions and drug access should be considered [].
Initiation of empiric therapy with pangenotypic regimens (Glecaprevir/Pibrentasvir or Sofosbuvir/Velpatasvir) is strongly favored, because the donor genotype is usually unknown at the time of organ allocation and these regimens feature a high barrier to resistance, which successfully overcomes potential baseline mutations, that are more common in Genotype 1a and Genotype 3. Once post-transplant testing confirms the specific genotype, clinicians can consider to safely switch the patient to targeted, genotype-specific options on the basis of drug interaction profiles and local cost-effectiveness []. In seronegative patients who receive seropositive viremic allografts, detectable HCV RNA levels as early as 3 days post-transplant have been observed []. Peri transplantation (before or soon after transplant within the first week) DAA therapies, that fully prevent the development of viremia, are likely to further mitigate any HCV-associated risks for adverse outcomes, but delayed treatment (after detectable HCV RNA or at 1 month after transplant) and shortened duration approach is common and might be feasible [, ]. HCV surveillance and treatment protocol for the recipients of HCV Ab positive, HCV RNA negative/positive donors based on expert opinion are summarized in Table 1.
TABLE 1
| Donor | Recipient |
|---|---|
| | • HCV Ab (+), HCV RNA (−) • HCV Ab (−), HCV RNA (−) |
| HCV Ab (+), HCV RNA (+) | • Baseline recipient HCV RNA before transplant • check HCV RNA early after transplant (3–7 days after transplant) • Repeat HCV RNA frequently (weekly or per center protocol) up to 4–6 weeks after transplant • Start DAA therapy with a prophylactic or preemptive strategy as soon as the recipient is clinically stable and able to take oral medications • Continue treatment for the recommended course and check HCV RNA every 4 weeks until confirm that sustained virologic response at 12 weeks is achieved |
| HCV Ab (+), HCV RNA (−) | • Baseline recipient HCV RNA before transplant • check HCV RNA after transplantation at 1- 3 and 6 months • If HCV RNA positive: Start DAA therapy |
HCV surveillance and treatment protocol for the recipient of HCV Ab positive, HCV RNA negative/positive donors for liver and non-liver organs.
Abbreviations: HCV, ab, HCV: Hepatitis C Virus antibody; DAA, Direct-Acting Antiviral; RNA, ribonucleic acid.
However, despite a clear decrease in discard rates, HCV positive allografts remain an underutilized resource, especially for liver transplantation []. Main barriers include insurance consent for DAA therapy, that is a primarily a challenge in specific countries like United States, or logistical issues through national centralized or local procedures []. Current studies have demonstrated similar short-term and long-term outcomes in patients transplanted with HCV viremic donors with sustained virologic response after DAA therapy, compared to non-HCV donors, even for patients undergoing re-transplantation and multivisceral transplantation [–26]. Recent studies on HCV discordant liver transplants demonstrated the excellent survival of these organs, with low rates of relapse and similar graft survival regardless of HCV viremia or allograft fibrosis [27, 28]. Although late recurrence of HCV is rare with modern DAA, it remains a threat to necessitating surveillance for potential relapse.
Altogether current literature shows a significant increase of HCV D+/R− transplantation, underscore the safety and cost-effectiveness of this practice and support the expansion of this practice further [29, 30] However, it is essential to continue to provide full informed consent and ensure adequate access to DAA therapy in the peri-transplant period.
Hepatitis B and hepatitis D
HBV positive donors are another potential opportunity to expand the donor pool. However, organ discard is frequent due to concerns for recipient HBV infection post-transplant and outcomes.
The risk of transmission must be stratified based on donor and recipients HBV serologic status as well as the organ transplanted, with liver being at higher risk [31, 32]. Transplantation into a recipient without serological evidence of prior HBV infection or vaccination carries the highest risk of transmission. Therefore, administration of HBV vaccination before transplantation is strongly recommended, but vaccination rates fell short of recommendations [33]. Moreover, effective nucleos(t)ide analog (NA) therapies are being used as posttransplant prophylaxis to decrease the rate of transmission depending on the donor and recipient serological profile (Table 2). Currenltly tenofovir disoproxil fumarate, tenofovir alafenamide, and entecavir are currently preferred over lamivudine due to their higher genetic barrier to resistance and to their superior antiviral potency [34].
TABLE 2
| Donor | Recipient | Recipient | Recipient |
|---|---|---|---|
| HBcAb positive HBsAg negative | • HBsAg (−); HBsAb (−); HbcAb (+) • HBsAg (−); HBsAb (+) ° *; HBcAb (−) • HBsAg (−); HBsAb (−); HBcAb (−)- | • HBsAg (−); HBsAb (+) °; HBcAb (+) | • HBsAg (+) |
| Prophylaxis and monitoring | Prophylaxis and monitoring | Prophylaxis and monitoring | |
| Liver • NA lifelong prophylaxis • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function • Every 6–12 months: liver ultrasound + AFP | Liver • NA lifelong prophylaxis or according to center policy • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function • Every 6–12 months: liver ultrasound + AFP | Liver • NA lifelong ± HB Ig (short § or long‐term ^) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function • Every 6–12 months: liver ultrasound + AFP | |
| Non liver organs • No prophylaxis • Every 3 months during the first 6 months: liver function, HbsAg, HBV DNA • Every 6 months later on after 6 months post-transplant: liver function, HBsAg, HBV DNA, liver function | Non liver organs • No prophylaxis or according to center policy • Every 3 months during the first 6 months: liver function, HBsAg, HBV DNA • Every 6 months later on after 6 months post-transplant: liver function, HBsAg, HBV DNA, liver function | Non liver organs • NA lifelong +/- HBIg intraoperatively • Every 3 months during the first 6 months: liver function, HBsAg, HBV DNA • Every 6 months later on after 6 months post-transplant: liver function, HBsAg, HBV DNA, liver function • Every 12 months: screening for HCC with abdominal ultrasound and AFP | |
| HBsAg positive HDV-RNA negative | HBsAg (−); HBsAb (+) °; HBcAb (+) HBsAg (−); HBsAb(+) ° *; HBcAb (−) | HBsAg (−); HBsAb (−); HBcAb (−) HBsAg (−); HBsAb (−); HBcAb (+) | HBsAg (+) HDV negative |
| Prophylaxis and monitoring | Prophylaxis and monitoring | Prophylaxis and monitoring | |
| Liver • NA lifelong + HB Ig (short = or long‐term ^) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function • Every 6–12 months: liver ultrasound + AFP | Liver • NA lifelong + HB Ig (short = or long‐term ^) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function • For liver: Every 6–12 months: liver ultrasound + AFP | Liver • NA lifelong DO + HB Ig (short = or long‐term ^) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function • Every 6–12 months: liver ultrasound + AFP | |
| Non liver organs • NA 6–12 months + HB Ig (short) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function | Non liver organs • NA 6–12 months + HB Ig (short) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function | Non liver organs • NA lifelong DO + HB Ig (short = or long‐term ^) • Every 3 months during the first year: liver function, HBsAg, HBV DNA • Every 3–6 months indefinitely: liver function, HBsAg, HBV DNA, liver function |
HBV surveillance and treatment protocol for the recipient of HBV positive donors according to recipient serological status.
Abbreviations: AFP, alpha fetoprotein; anti-HBc, Hepatitis B anti-core antibody; anti-HBs, Hepatitis B surface antibody; HBsAg, Hepatitis B surface antigen; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; NA, nucleos(t)ide analog.
Symbols: ° (title >10 mlU/mL); *vaccinated; § short: 1–7 days; ^ long term: one year-lifelong for HBV-HIV, or HBV-HDV, coinfected patients. To maintain an HBsAb titer of 50–500 IU/mL, depending on the recipient’s risk level.
Liver transplantation from HBV core antibody (antiHBc Ab) donor carries a high risk (on average around 50%) of transmitting hepatitis B to the recipient. A serological profile indicative of previous contact with HBV is preferable in the recipient. However, liver transplantation in HBsAg/HBsAb negative patients is possible, but prophylactic treatment and constant post-transplant monitoring is recommended. Similar short- and long-term graft and patient survival rates have been observed when compared with HBcAb negative grafts [, 35].
Non hepatic transplantation of HBV core positive organs does not pose any additional risk to patients with a serological profile indicative of previous contact with HBV. Non liver transplantation from antiHBc Ab positive donors in HBsAg/HBsAb negative patients poses a particularly low risk of transmitting HBV to the recipient, but this risk is not absent and deserve monitoring and/or prophylaxis according to the center policy [35, 36].
Use of organs from donors with HBV infection, defined as detection of hepatitis B surface antigen (HBsAg) or detectable HBV DNA is a potential opportunity to increase organ availability, including in naïve non vaccinated recipients [37, 38]. Successful liver transplants have been performed using HBV-infected donors with similar outcomes as HBsAg negative liver grafts without excess mortality, graft loss, or post-transplant HBV-related complications. There are limited studies reporting on the safety and outcomes using HBV-positive donors for non-hepatic organ transplants, but strongly supporting this practice [39]. Of note that fulminant hepatitis in recipients of hepatic and non-hepatic grafts has been described [38, 39].
Quantifying HBV viral loads has proven to support optimization of recipient risk stratification and management in the prevention of DDI [39]. There is a lack of standardized antiviral prophylaxis and long term follow up, that should be personalized based on expert opinion (Table 2). Post-transplant monitoring of liver function, HBsAg/HBcAb seroconversion and HBV quantitative detection is recommended. Pre-transplant HBV vaccination is strongly recommended. Transplant recipients of HBsAg+ organs should receive human HBV immunoglobulin (Ig) against HBsAg, starting during the intraoperative phase, in association with a high barrier NA regardless of the immune status. The initial objective is to maintain an anti-HBs titer >50–500 IU/L, depending on the recipient’s specific risk stratification for recurrence The duration of HB Ig therapy varies according to the transplanted organ and the presence of other coinfections, since recipients of non-liver organs from HBsAg-positive donors generally require short (1–7 days) HB Ig maintenance, whereas long-term (at least 1 year) or lifelong HB Ig combination therapy remains the standard of care for liver transplant recipients, particularly those with HIV/HBV or HBV/HDV coinfection (Table 2) [40, 41].
Hepatitis D virus (HDV)/HBV coinfection merits further comments. HDV is a small defective RNA virus that requires the surface antigen of the hepatitis B virus for its replication, assemblage, and transmission. HDV donor screening is recommended in HBsAg positive donors, whereas the presence of HBV-DNA alone in the absence of HBsAg does not require screening for HDV virus. HDV infection is documented by a positive HDV antigen or positive anti-HDV IgM (a negative HDV IgM result does not exclude chronic HDV infection) or anti-HDV IgG with a titer >1:100. If anti-HDV is positive, follow up with HDV RNA testing is recommended to confirm active infection. Organ allocation must be done on the basis of donor and recipient screening due to the risk of HDV superinfection or recurrence (Table 3) [42]. HDV/HBV-coinfected liver transplant recipients do not represent a risky population compared with HBV infected patients in general, but further data on use of HDV/HBV positive organs in HDV/HBV positive recipients are needed [43]. Currently there is no approved treatment for HDV after transplant due to poor Interferon efficacy and limited role of bulevirtide in the context of liver transplantation. As thing stand now, the most effective method for preventing HDV infection of transplanted liver in these patients is dependent on preventing HBV recurrence, with an indefinite combination of NAs with HB Ig. [44, 45]. HBV vaccination remains the cornerstone of prevention of HBV and HDV [46].
TABLE 3
| Donor | Recipient | Recipient |
|---|---|---|
| | • HBsAg positive • HDV RNA positive | • HBsAg positive • HDV RNA negative |
| HBsAg positive HDV RNA positive | transplant allowed | transplant of any organ not recommended: Risk of fatal HDV superinfection |
| HBsAg positive HDV RNA negative | liver transplant not recommended: Risk of HDV hepatitis recurrence | transplant of any organ allowed |
Organ allocation in HDV/HBV coinfected donors and recipients.
In conclusion the use of antiHBc and HBsAg+ grafts was is and feasible and might play an important role in expanding donor organs especially in area of high prevalence of HBV infection. However, more data are needed to study the long-term risk of DDI HBV infection and define the optimal management strategies.
Hepatitis E
Hepatitis E virus (HEV) is an RNA virus and a major cause of acute hepatitis worldwide. HEV has 8 genotypes, but most infections are due to genotypes HEV-1 and HEV-2, that are associated with fecal-oral route via contaminated drinking water in low-income countries and to HEV-3 and HEV-4, that are related with foodborne zoonotic infections in developed regions. HEV-3 is the dominant strain in Europe and the Americas, while HEV-4 predominates in Asia (China).
In immunocompetent hosts, HEV typically causes a self-limited acute hepatitis, whereas in SOT recipients, HEV infection can cause chronic hepatitis (defined by replication beyond 3 months after infection), that can occur in around two-thirds of infected SOT. Moreover, HEV in SOT can lead to cirrhosis, graft dysfunction or rejection [47]. Persistent hepatitis E occurs primarily involving HEV-3 and 4 [48].
Transmission of HEV through solid organs is very efficient (especially for higher plasma viral load > 103 IU/mL), particularly through liver grafts and highlights the importance of surveillance and screening protocols []. The decision to implement universal organ donor and recipient HEV screening depends on HEV incidence, since in regions with low baseline HEV prevalence routine universal screening yields minimal impact on overall transplant safety [, 49, 50].
The screening method of choice includes both serology (HEV IgM, IgG) and PCR testing. HEV-RNA is more sensitive than serologic testing [51]. Undetectable HEV-RNA in donor serum would indicate low risk for HEV transmission, although liver grafts may harbor infectious HEV RNA even in the absence of systemic markers of infection [51]. Donor testing result for HEV infection might be done pre- or post-transplant. Detection of HEV RNA in donor plasma is not a contraindication for organ donation, but triggers improved recipient management. Managing strategies for donor derived HEV infection is based on early detection of infection (HEV-RNA weekly for the first month) and reduction of immunosuppression (especially mammalian target of rapamycin (mTOR) inhibitors and tacrolimus). In addition, for patients without spontaneous viral clearance after 1 month, a 3-month course of ribavirin is recommended, achieving sustained virologic response in approximately 80% of cases (Table 4) [52].
TABLE 4
| Donor | Management of the recipient |
|---|---|
| HEV IgM or IgG positive HEV RNA negative | • Accept organs • Post-transplant surveillance of the recipient: HEV-RNA every 2–3 months for the first year after transplant |
| HEV RNA positive | • Consider accepting organs • Post-transplant surveillance of the recipient: HEV-RNA weekly for the first month • If HEV-RNA positive in the recipient (after 1 month) o Liver test at month 1; HEV-RNA in serum and stool at month 2 and 3 o Pre-emptive ribavirin soon after transplant (starting 1–3 months after transplant depending on individual risk factors * o Change of immunosuppression, if possible • If HEV-RNA negative in the recipient (after 1 month) oHEV serology after 3 months |
| Recipient | |
| HEV IgM or IgG positive and HEV-RNA negative | • Proceed with listing and transplantation • Post-transplant surveillance of the recipient: HEV-RNA every 2–3 months for the first year after transplant |
| HEV RNA positive | With normal liver function: • Proceed with active transplant listing • Monitor HEV RNA • Plan for post-transplant ribavirin therapy if needed Without normal liver function • Delay transplantation if possible • Prioritize early ribavirin administration prior to the transplant • Change of immunosuppression, if possible |
Management of recipient based on donor and recipient serological and virological Markers of Hepatitis E.
*Risk factors to consider: liver transplant, marginal liver graft, underling liver disease, polyclonal antibodies induction.
Vaccination against HEV represents a promising prophylactic tool, though availability remains geographically restricted (licensed in China and Pakistan) [53].
HIV
Overall, there is increasing and solid literature supporting transplantation in people with HIV [54]. However, opportunities exist to improve knowledge and overcome misconceptions about SOT for people with HIV. At the European level, the use of organs from HIV D+ is legally allowed only in 6 out of 35 (17%) countries and there is a high willingness to participate in an HIV D+/R+ among experts in the field [55]. Moreover, awareness of the ability of patients with HIV to both receive and donate organs is limited [56]. Since the 2015, HOPE Act prospective studies have demonstrated that kidney and liver transplantation from HIV D+/R+ recipients are safe and effective, with similar graft and patient survival to HIV D−/R+ transplantation. Moreover donor-derived HIV superinfection in recipients of HIV D+/R+ transplants is rare, and the clinical ramifications appear negligible [57].
A recent retrospective small experience after heart transplantation in HIV-positive recipients using HIV-positive or HIV-negative donors (4 HIV D +/R+, 6 HIV D -/R+) found no significant differences in short-term survival, rejection, infection, heart graft function and HIV suppression between both groups at 6 months. Moreover, the lack of difference in donor-derived cell free DNA provided reassurance that use of hearts from HIV D+ did not trigger increased myocyte injury [58]. This early experience provides evidence and the inclusion of cardiothoracic patients in trials might be a necessary evolutionary step [59, 60].
Prior to 2017, transplants from HIV-positive donors to HIV-negative recipients occurred only inadvertently, because the donor’s positive HIV status was discovered after the organs had been transplanted. In 2017, the first intentional liver transplantation from a living HIV-positive mother to an HIV-negative child was performed. Multidisciplinary evaluation, research trial approval and specific consent to the procedure were obtained [61]. The recipient started antiviral therapy before the transplantation to minimize the risk of HIV transmission, continued it after transplantation. No plasma or cell-associated HIV-1 DNA or RNA was detected at any stage in the recipient, although the child’s HIV status was uncertain [61].
Thanks to modern highly effective antiviral therapy, the use of organs from deceased donors with HIV for HIV-negative recipients might become a medical consideration in the future, allowing to expand the donor pool. However, this approach requires strict precautions against transmission and deeply informed, voluntary patient consent to manage the remaining ethical and clinical complexities [59, 60].
Human herpesvirus 8
Human herpesvirus 8 (HHV-8) is an emerging topic in DDI. HHV-8 is a double-stranded DNA virus, whose life cycle is similar to that of other herpesviruses. Primary infection is usually asymptomatic in immunocompetent hosts. However, HHV-8 primary infection or reactivation in immunocompromised hosts can lead to a spectrum of diseases, ranging from malignancies (Kaposi Sarcoma- KS-, Primary Effusion Lymphoma, Diffuse Large B-cell Lymphoma and Multicentric Castleman Disease) to severe inflammatory syndromes (Kaposi Sarcoma Herpesvirus Inflammatory Cytokine Syndrome, KICS).
HHV-8 prevalence varies with geography and ethnicity. Variable ranges have been observed in North Europe (5%), United States (3%–7%), the Mediterranean (20%–30%) and Sub-Saharan Africa (> 50%). Moreover, seroprevalence is influenced by behavioral risk, being significantly increased in people living with HIV, especially in men who have sex with men (MSM) [62]. In particular a recent study performed in Unites States found a higher prevalence of HHV-8 among kidney donors with HIV compared with non-HIV (25.2% and 7.5%, respectively), particularly among MSM [63].
In the context of SOT, HHV-8 might cause a DDI, whose timing, clinical picture and severity depends on several factors. D+/R-serological status might favor primary infection that is usually associated with inflammatory syndromes and aggressive visceral forms of KS. Moreover, the degree of immunosuppression and lung and liver transplants tend to be associated with more severe disease forms and poorer outcome.
Implementation of universal HHV-8 screening for donors and recipients should be primarily driven on one hand by local HHV-8 incidence and resource availability and on the other hand by the disproportionate severity of donor-derived post-transplant infections. A targeted screening strategy based on donor risk factors could balance safety while avoiding the economic burden of universal screening. In non-endemic areas, HHV-8 testing could be prioritized for donors presenting specific epidemiological or behavioral risk profiles, such as a history of recent incarceration, injection drug use, high-risk sexual behavior, HIV coinfection or origin from highly endemic regions [62]. In addition, there is a lack of standardized screening since Enzyme-Linked Immunosorbent Assay (ELISA) has a poor performance and may miss antibodies that target specific latent-phase proteins, whereas Indirect Immunofluorescence Assay (IFA) is the preferred approach but is operator dependent [62].
Greater awareness of risk through pre-transplant screening could support accurate and timely diagnosis, enabling earlier therapeutic intervention and potentially reducing morbidity and mortality associated with HHV-8 DDI. Strict clinical and molecular monitoring is strongly recommended for high-risk patients (HHV-8 mismatch D+/R- or R+). In addition, in case of persistent HHV-8 DNAemia and symptomatic infections, switch to an immunosuppressive regimen by replacing calcineurin inhibitors with mammalian target of rapamycin (mTOR) inhibitors and antiviral treatment (foscarnet or cidofovir, that are preferred over ganciclovir) are recommended, although use of antivirals is debatable in this setting. In the case of KICS, rituximab might be additionally provided (Table 5) [].
TABLE 5
| Donor and recipient | Monitoring | Treatment |
|---|---|---|
| HHV8 D+/R– HHV8 D+/- and R+ | HHV8 DNA test • Every 15 days for the first 3 months • Monthly between the 4th and 12th month • From the 12th month onwards, in anti-HHV-8 positive recipients repeat HHV-8 DNA testing during routine check-ups and during treatment for acute rejection/intensification of immunosuppression • Skin self-examination for detection of KS-like lesions | Primary infection or reactivation with persistent positive HHV-8 DNA and symptomatic infection • Start an antiviral (foscarnet or cidofovir preferred over ganciclovir) • Replacement of CNIs with mTOR inhibitors, when feasible • If confirmed KICS, additional rituximab • If confirmed KS: use Liposomal Doxorubicin • If confirmed MCD, PEL: follow specific treatment guidelines |
Recommended monitoring and intervention for HHV-8 high risk recipient (HHV8 D+/R–and R +).
Abbreviations: CNIs, calcineurin inhibitors; DNA, deoxyribo nucleic acid; KS, kaposi sarcoma; KICS, kaposi sarcoma inflammatory cytokine syndrome; mTOR, mammalian target of rapamycin; MCD, multicentric castleman disease; PEL, primary effusion lymphoma.
Respiratory viruses
Respiratory viruses have been largely unknown and underestimated as a cause of DDI. The SARS-CoV-2 pandemic and the increased use of molecular testing have raised awareness of the role of respiratory viruses in respiratory tract infections, including in the context of DDI [64–66].
In general, transplantation of non-lung organs from donors with active respiratory viral infection is considered possible and well tolerated, without transmission, except in case of organ specific contra-indications (for example myocarditis, hepatitis). Since major transplant societies offer limited guidance, the utilization of these organs is determined by individual centers, leading to significant variations in practice at both national and international levels. In contrast, lung and bowel recipients remain uniquely vulnerable due to the high likelihood of direct viral transmission in the respiratory or gastrointestinal tracts, depending on the type of virus. In general lungs should not be used from donors with proven respiratory viral infection as the primary cause of death or causing clear lower respiratory tract involvement. However, since molecular testing detects viral RNA/DNA even in the absence of active, infectious virions, this approach is associated with the risk of wasting organs that could otherwise be safely transplanted [67].
Most available literature is focused on SARS-CoV-2 []. As thing stand now, current strategies for donor evaluation still include universal microbiologic screening with standard SARS-CoV-2 PCR of lower respiratory tract 24–72 h before organ procurement in most countries worldwide [68, 69]. Because of the absence of the risk of transmitting SARS-CoV-2 through non-lung solid organs, some experts propose that universal, routine testing of asymptomatic, non-lung deceased donors should be re-evaluated [68]. Of interest that a recent Italian study found that molecular testing for SARS-CoV-2 RNA on 64 graft biopsies (liver and kidney) and 68 perfusion fluid samples at procurement were negative in 100% of cases, including in donors with lower respiratory tract samples with a high viral load (Ct value <30) [70]. Lung transplantation from SARS-CoV-2 is generally contraindicated, but careful consideration to proceeding might be done based on risks and benefits, generally provided that lower respiratory tract testing is negative and antivirals are administered to the recipient [67, 71].
The use of organs from donors with positivity for Rhinovirus/Enterovirus, seasonal Coronavirus, Influenza, Paramyxovirus (Parainfluenza Virus, Human Metapneumovirus-MPV-, Respiratory Syncytial Virus-RSV-), Adenovirus and Boacavirus is a challenging topic, due to limited available data [72–74]. Screening for respiratory viral pathogens other than SARS-CoV-2 at donor evaluation is not recommended routinely and is usually conducted only in symptomatic donors. Moreover, deepening on guidelines, screening might be limited only to Influenza virus during epidemic periods or might include a complete multiplex PCR panel [75]. Therefore, the true incidence and burden of these diseases remain poorly understood. Certain viruses, namely Influenza and those from the Paramyxovirus are more likely to be associated with lower respiratory tract infections, higher hospitalization rates compared with Rhinovirus/Enterovirus and seasonal Coronavirus in lung transplant recipients [76]. Particular attention should be paid to Adenovirus-positive donors, given the virus propensity to cause systemic dissemination or end-organ damage in immunocompromised recipients depending on the virus serotype and the organ involved and to influenza A/H5N1 for the higher risk of viremia [73, 77]. However, there is limited reported evidence to support systematic viral testing of donor respiratory specimens, with a concrete risk of difficult to interpret result and discard of low-risk donors.
Most available literature on risk of DDI is based on influenza virus. There is currently no evidence demonstrating transmission of the virus through transplantation of non-lung organs, nor evidence of increased morbidity among recipients of these organs [69]. There are 2 reports of possible transmission of seasonal influenza A and B viruses by transplantation of lungs and kidneys from infected donors, but detailed molecular proof was lacking [78, 79]. Some experts recommend that recipients of organs from influenza positive donors should receive antiviral treatment for 5–10 days following transplant, unless the donor has already received a full course of treatment to reduce severity and infectivity [80]. Of note that a recent case report described a case of fatal acute respiratory distress syndrome caused by donor-derived human MPV after lung transplantation from an asymptomatic donor, confirmed after next-generation sequencing of MPV genomes [81]. Further studies are essential to precisely quantify the transmission risks of respiratory viruses during lung transplants to refine diagnostic and screening protocols.
Maintaining up-to-date vaccinations for circulating respiratory viruses in transplant candidates is crucial to mitigating risk. In general, recipients should be protected with vaccination against SARS-COV-2, influenza and RSV [82].
Conclusion
Balancing the transmission risk of viral DDIs against the high risk of waitlist mortality is crucial, because of the growing ethical imperative to ensure equitable transplant access. By comprehensively understanding donors at risk for viral infections and their potential clinical consequences, transplant teams can perform targeted mitigation strategies, through rigorous pretransplant and posttransplant microbiological testing and target therapies.
However, the current clinical landscape is significantly limited by a lack of standardized consensus screening and management protocols for old and emerging risk viruses. Future research priorities in DDI viral infections should focus on improving the current use of post-transplant quantitative molecular testing and on exploring the role of post-exposure prophylaxis against preemptive treatment strategies in recipients. Moreover, clinical trials are urgently required through evaluating the role new advanced diagnostics, including rapid metagenomic next-generation sequencing, and new novel therapeutics, as well as virus-specific T-cell immunotherapies. Finally, coordinated financial and infrastructural investments are needed to strengthen epidemiological vigilance registries and communication networks to ensure rapid trace-backs investigations.
Statements
Author contributions
Writing, editing and review: MP and PG. All authors contributed to the article and approved the submitted version.
Funding
The author(s) declared that financial support was not received for this work and/or its publication.
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Abbreviations
anti-HBc, Hepatitis B anti-core antibody; anti-HBs, Hepatitis B surface antibody; DDI, donor derived infection; DAA, direct-acting antivirals; HBsAg, Hepatitis B surface antigen; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV, Human Immunodeficiency Virus; KS, Kaposi Sarcoma; KICS, Kaposi Sarcoma Inflammatory Cytokine Syndrome; MSM, men who have sex with men; NA, nucleos(t)ide analog; NAT, nucleic acid amplification test; PCR, polymerase chain reaction; SARS-CoV-2, Severe Acute Respiratory Syndrome Coronavirus 2.
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Summary
Keywords
donor derived infection/transplant infection, HHV-8, HIV, respiratory viral infections, viral hepatitis
Citation
Peghin M and Grossi PA (2026) Donor-derived viral infections: the usual suspects and the new kids on the block. Transpl. Int. 39:17050. doi: 10.3389/ti.2026.17050
Received
31 May 2026
Revised
23 August 2026
Accepted
01 September 2026
Published
10 September 2026
Volume
39 - 2026
Updates
Copyright
© 2026 Peghin and Grossi.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Paolo Antonio Grossi, paolo.grossi@uninsubria.it
Disclaimer
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