REVIEW
Transpl. Int.
Back in Circulation: A review of the implementation of thoracoabdominal normothermic regional perfusion in donation after circulatory death in lung transplantation
- AN
Anna Niroomand 1
- SC
Stephanie Chang 2
- SL
Sandra Lindstedt 1,3
1. Wallenberg Centre for Molecular Medicine, Faculty of Medicine, Lund University, Lund, Sweden
2. NYU Langone Health, New York, United States
3. Skanes universitetssjukhus Lund, Lund, Sweden
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Abstract
In the face of a growing mismatch between candidates awaiting transplantation and the supply of conventional donor organs, attention has shifted toward novel methods to increase the donor pool, including the use of donation after circulatory death (DCD) and the refinement of procurement techniques that safeguard graft quality. Thoracoabdominal normothermic regional perfusion (TA-NRP) has emerged as a new strategy, leveraging extracorporeal support to curtail warm-ischemic injury while permitting in-situ functional assessment. This review covers the rationale behind the use of TA-NRP, while outlining its use during procurement and the current body of evidence that gathered on its implementation in lung transplantation specifically.
Summary
Keywords
DCD, Donation after Circulatory death, lung transplantation, TA-NRP, thoracoabdominal normothermic regional perfusion
Received
14 July 2025
Accepted
23 March 2026
Copyright
© 2026 Niroomand, Chang and Lindstedt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Sandra Lindstedt
Disclaimer
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