POINT OF VIEW

Transpl. Int.

Volume 38 - 2025 | doi: 10.3389/ti.2025.13622

This article is part of the Special IssueEuropeans and XenotransplantationView all 17 articles

The future of pig liver xenotransplantation

  • Department of Clinical Science, Intervention and Technology, Karolinska Institutet (KI), Stockholm, Sweden

The final, formatted version of the article will be published soon.

Recent technological advances in genetic engineering have led to a renewed interest in xenotransplantation. Milestones achievements in heart, kidney and more recently liver xenotransplantation raise the hope of an alternative source of organs and pave the way for first in human clinical trials. With these rapid developments, it is important to consider what may be the place of liver xenotransplantation in the treatment armamentarium and what are the challenges to achieve clinical liver xenotransplantation.

Keywords: liver transplant, Xenotransplantation, cross circulation, auxiliary liver transplantation, decedent model

Received: 06 Aug 2024; Accepted: 25 Jun 2025.

Copyright: © 2025 Karadagi and Oniscu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Gabriel C Oniscu, Department of Clinical Science, Intervention and Technology, Karolinska Institutet (KI), Stockholm, Sweden

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