CASE REPORT
J. Cutan. Immunol. Allergy
Case Report: Dermatomyositis with symmetrical axillary and inguinal panniculitis associated with anti-NXP-2
- EU
Eri Uchiyama 1
- AS
Akira Shimizu 1
- MT
Mei Tochigi 1
- YT
Yuko Takamiya 1
- TM
Takashi Matsushita 2
- KY
Kazunori Yamada 1
1. Kanazawa Medical University, Uchinada, Japan
2. Kanazawa Daigaku, Kanazawa, Japan
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Abstract
We report a rare case of dermatomyositis in a woman in her 60s, presenting with chronic pruritic erythema and symmetrical subcutaneous indurations in both axillae. Physical examination revealed Gottron's papules and erythematous plaques on the hands and upper extremities. Laboratory tests showed mildly elevated serum CK, aldolase, and CRP levels. CT revealed increased fat density in both axillae, suggestive of panniculitis. Skin and subcutaneous biopsies confirmed interface dermatitis and panniculitis with membranocystic changes. After that, bilateral inguinal panniculitis developed. Autoantibody screening identified strong positivity for anti-NXP-2 and anti-Ki antibodies. Anti-NXP-2 antibody was further confirmed by immunoprecipitation-Western blotting. The diagnosis of dermatomyositis was made, and oral prednisolone (10mg, 0.2mg/kg/day) led to marked improvement. These findings may suggest a potential association between anti-NXP-2 antibodies and panniculitis.
Summary
Keywords
dermatomyositis, anti-NXP-2 antibody, anti-Ki antibody, panniculitis, A-cube®
Received
19 October 2025
Accepted
20 November 2025
Copyright
© 2025 Uchiyama, Shimizu, Tochigi, Takamiya, Matsushita and Yamada. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Akira Shimizu, ashimizu@kanazawa-med.ac.jp
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