@ARTICLE{10.3389/ti.2023.10841, AUTHOR={Tanaka, Sébastien and Tymowski, Christian De and Tran-Dinh, Alexy and Meilhac, Olivier and Lortat-Jacob, Brice and Zappella, Nathalie and Jean-Baptiste, Sylvain and Robert, Tiphaine and Goletto, Tiphaine and Godet, Cendrine and Castier, Yves and Mal, Hervé and Mordant, Pierre and Atchade, Enora and Messika, Jonathan and Montravers, Philippe and , the Bichat Lung Transplant Group and Abadie, Agnès and Atchade, Enora and Ben-rehouma, Mouna and Bunel, Vincent and Castier, Yves and Cerceau, Pierre and Ferreira, Diego and Frere, Gwenn and Genet, Lucie and Godet, Cendrine and Goletto, Tiphaine and Jean-Baptiste, Sylvain and Jebrak, Gilles and Kantor, Elie and Labed, Paul and Longrois, Dan and Lortat-Jacob, Brice and Mal, Hervé and Marceau, Armelle and Medraoui, Chahine and Menonville, Charlotte Thibaut de and Messika, Jonathan and Mignon, Alexandre and Mouren, Domitille and Pellenc, Quentin and Renard, Régis and Roussel, Arnaud and Salpin, Mathilde and Sandrine Boudinet, Léa Copelovici and Savary, Alice and Senemaud, Jean and Snauwert, Aurélie and Stern, Jules and Tanaka, Sebastien and Tashk, Parvine and Tissot, Sandrine and Tran-Dinh, Alexy and Trigueiros, Sabrina and Tymowski, Christian de and Weisenburger, Gaëlle and Zappella, Nathalie}, TITLE={Low HDL-Cholesterol Concentrations in Lung Transplant Candidates are Strongly Associated With One-Year Mortality After Lung Transplantation}, JOURNAL={Transplant International}, VOLUME={36}, YEAR={2023}, URL={https://www.frontierspartnerships.org/articles/10.3389/ti.2023.10841}, DOI={10.3389/ti.2023.10841}, ISSN={1432-2277}, ABSTRACT={High-density lipoproteins (HDLs), whose main role is the reverse transport of cholesterol, also have pleiotropic anti-inflammatory, antioxidant, anti-apoptotic and anti-infectious properties. During sepsis, HDL cholesterol (HDL-C) concentration is low, HDL particle functionality is altered, and these modifications are correlated with poor outcomes. Based on the protective effects of HDL, we hypothesized that HDL-C levels could be associated with lung transplantation (LT) outcome. We thus looked for an association between basal HDL-C concentration and one-year mortality after LT. In this single-center prospective study including consecutive LTs from 2015 to 2020, 215 patients were included, essentially pulmonary fibrosis (47%) and chronic obstructive pulmonary disease (COPD) (38%) patients. Mortality rate at one-year was 23%. Basal HDL-C concentration stratified nonsurvivors to survivors at one-year (HDL-C = 1.26 [1.12–1.62] mmol/L vs. HDL-C = 1.55 [1.22–1.97] mmol/L, p = 0.006). Multivariate analysis confirmed that HDL-C concentration during the pretransplant assessment period was the only variable inversely associated with mortality. Moreover, mortality at one-year in patients with HDL-C concentrations ≤1.45 mmol/L was significantly higher (log-rank test, p = 0.00085). In conclusion, low basal HDL-C concentrations in candidates for LT are strongly associated with mortality after LT. To better understand this association, further studies in this field are essential and, in particular, a better characterization of HDL particles seems necessary.} }