%A Jung,Hee-Yeon %A Jeon,Yena %A Huh,Kyu Ha %A Park,Jae Berm %A Kim,Myung-Gyu %A Lee,Sik %A Han,Seungyeup %A Ro,Han %A Yang,Jaeseok %A Ahn,Curie %A Cho,Jang-Hee %A Park,Sun-Hee %A Kim,Yong-Lim %A Kim,Chan-Duck %D 2022 %J Transplant International %C %F %G English %K kidney transplantation,alcohol,all-cause mortality,biopsy-proven acute rejection,cardiovascular events,death-censored graft failure,low-density lipoprotein cholesterol,total cholesterol %Q %R 10.3389/ti.2022.10243 %W %L %M %P %7 %8 2022-May-30 %9 Original Research %# %! Alcohol consumption and KT outcomes %* %< %T Pretransplant and Posttransplant Alcohol Consumption and Outcomes in Kidney Transplantation: A Prospective Multicenter Cohort Study %U https://www.frontierspartnerships.org/articles/10.3389/ti.2022.10243 %V 35 %0 JOURNAL ARTICLE %@ 1432-2277 %X The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo, or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol (p < 0.001) and low-density lipoprotein cholesterol levels (p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels (p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile.Clinical Trial Registration:clinicaltrials.gov, identifier NCT02042963.