%A Rosales-Reynoso,M. A. %A Rosas-Enríquez,V. %A Saucedo-Sariñana,A. M. %A Pérez-Coria,M. %A Gallegos-Arreola,M. P. %A Salas-González,E. %A Barros-Núñez,P. %A Juárez-Vázquez,C. I. %A Flores-Martínez,S. E. %A Sánchez-Corona,J. %D 2022 %J British Journal of Biomedical Science %C %F %G English %K Breast cancer,AXIN2,TCF7L2,genotypes,haplotypes,susceptibility %Q %R 10.3389/bjbs.2021.10211 %W %L %M %P %7 %8 2022-January-25 %9 Original Research %# %! Genotypes and haplotypes in the %* %< %T Genotypes and Haplotypes in the AXIN2 and TCF7L2 Genes are Associated With Susceptibility and With Clinicopathological Characteristics in Breast Cancer Patients %U https://www.frontierspartnerships.org/articles/10.3389/bjbs.2021.10211 %V 79 %0 JOURNAL ARTICLE %@ 2474-0896 %X Background: Breast cancer is a multifactorial disease whose genetic susceptibility is related to polymorphic variants of cell proliferation and migration pathways. Variants in AXIN2 and TCF7L2 in the Wnt-β catenin pathway have been associated with different types of cancer; however, little is known about its role in breast cancer. This study tests the hypothesis of links between AXIN2 rs1133683 and rs2240308, and TCF7L2 rs7903146 and rs12255372 variants in breast cancer.Methods: Peripheral blood samples were obtained from 404 women (202 patients and 202 control females). The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology was used to identify the gene variants.Results: The AXIN2 rs2240308 (C > T), and TCF7L2 rs7903146 (C > T) and rs12255372 (G > T) variants were associated with breast cancer and with age, TNM stage, and histologic-molecular subtype (p = 0.001). Likewise, the haplotype T-T in the TCF7L2 gene (rs7903146-rs12253372) was significantly related with breast cancer (OR = 2.66, 95%, CI = 1.64–4.30, p = 0.001).Conclusion: Our data show a link between AXIN2 rs2240308 and TCF7L2 rs7903146 and rs12255372 variants in breast cancer, and speculate this may be important in pathogenesis.