About this Special Issue
Despite the explosion of biotechnology, genomics, and artificial intelligence, the pharmaceutical industry continues to look toward naturally derived polyphenol compounds for small molecule discovery. State of the art methodology is now used to enhance their understanding and for new discoveries. The pharmaceutical science behind such molecules is essential to use these agents both safely and effectively. Polyphenols are compounds that are commonly occurring in nature but can also be medicinally synthesized. Both animal and clinical studies demonstrate potential clinical utility of flavonoids and stilbenes in particular as anti-viral, anti-inflammatory, anti-oxidants for cardiovascular disease protection and as adjunctive cancer management. The detailed pharmaceutical comprehension and their clinical possibilities remain enormous and have been steadily evolving, with research interests developing world-wide and across diverse therapeutic areas to better understand structure and function relationships. Continued pharmaceutical research advancements are critical for the future development of effective evidence-based polyphenol therapies.
This Special Issue aims to publish studies relating to polyphenols including but not limited to flavonoids and stilbenes with a framework for fundamental concepts, enhanced understanding, and a pharmaceutical science focus on the analysis, pharmaceutics, biopharmaceutics, pharmacokinetics and potential as therapeutics, the status of existing treatments, toxicity and safety limitations of their use, potential formulation approaches, and the future array as therapeutics. This Issue aims to validate and extend the value and contemporary understanding of the utility and potential utility of these molecules.
We therefore welcome the pharmaceutical and biomedical community and clinicians to share their findings and insights from discovery and synthesis, to applications in cell culture, through pre-clinical animal findings, and pharmaceutical manufacturing into clinical trials involving various applied pharmaceutical innovations, using evidence-based data. A comprehensive coverage of all aspects of this exciting field will widen the community and up date and continue research and highlight the evidence-based therapeutic approaches that underpins this field. This Special Issue welcomes a wide range of diversity in input by seeking Original Research, Reviews, Mini Reviews, Case Reports, and Brief Research report articles, all of which will undergo full peer review.
For authors, please also review the journal's information regarding Author Guidelines and Article Processing Charges, or direct any questions to the Editorial Office. Submitting an abstract or a brief synopsis of the manuscript is not required.
Manuscript deadline: 1 February 2024
Keywords: polyphenol, flavonoid, stilbene, nutraceutical, pharmaceutical, anti-oxidant