Transpl. Int. Transplant International Transpl. Int. 1432-2277 Frontiers Media S.A. 15860 10.3389/ti.2025.15860 Correction Corrigendum: Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality Süsal et al. Tacrolimus CDR and Kidney Outcomes Süsal Caner 1 2 * † Döhler Bernd 1 † Demir Erol 2 3 † Ibrahim Walaa 4 † Askar Medhat 5 * † Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany Transplant Immunology Research Center of Excellence TIREX, Koç University School of Medicine, Istanbul, Türkiye Division of Nephrology, Department of Internal Medicine, Yeditepe University School of Medicine, Istanbul, Türkiye Department of Internal Medicine and Nephrology, Faculty of Medicine, Assiut University, Assiut, Egypt Health Sector and Department of Immunology, College of Medicine, Qatar University, Doha, Qatar Correspondence: Caner Süsal, csusal@ku.edu.tr; Medhat Askar, maskar@qu.edu.qa

ORCID: Caner Süsal, orcid.org/0000-0003-2521-8201; Bernd Döhler, orcid.org/0000-0003-0051-096X; Erol Demir, orcid.org/0000-0003-0128-5645; Walaa Ibrahim, orcid.org/0000-0002-3217-0544; Medhat Askar, orcid.org/0000-0003-2633-9363

17 12 2025 2025 38 15860 06 11 2025 06 11 2025 24 11 2025 Copyright © 2025 Süsal, Döhler, Demir, Ibrahim and Askar. 2025 Süsal, Döhler, Demir, Ibrahim and Askar https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. A Corrigendum on Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality by Süsal C, Döhler B, Demir E, Ibrahim W and Askar M (2025). Transpl. Int. 38:15207. doi: 10.3389/ti.2025.15207 Graphical Abstract

High tacrolimus metabolism is linked to increased kidney transplant failure and infection-related mortality. The study analyzed 21,865 kidney transplants from 2000 to 2019, the largest to date. About 25.2% had a low concentration-dose-ratio (CDR), predicting poor outcomes with a hazard ratio up to 2.80 and a 63% increase in infection-related mortality. Higher risk groups include females, young individuals, and those with CYP3A5*1A. Strategies like diltiazem co-medication and steroid tapering may improve long-term outcomes in patients with low CDR. Conducted by Caner Süsal, published in Transplant International.

kidney transplant tacrolimus concentration-to-dose ratio allograft loss mortality infection

In the published article, there was an error in the article title. Instead of “Hidden in Plain Sight: Low Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality”, it should be “Hidden in Plain Sight: High Tacrolimus Metabolism Doubles Kidney Transplant Failure and Drives Infection Related Mortality”.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

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