AUTHOR=Niroomand Anna , Nita George Emilian , Lindstedt Sandra 

TITLE=Machine Perfusion and Bioengineering Strategies in Transplantation—Beyond the Emerging Concepts

JOURNAL=Transplant International

VOLUME=Volume 37 - 2024

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.13215

DOI=10.3389/ti.2024.13215

ISSN=1432-2277

ABSTRACT=Solid organ transplantation has progressed rapidly over the decades from the first experimental procedures to its role in the modern era as an established treatment for end-stage organ disease. Solid organs including transplantation of the liver, kidney, pancreas, heart, and lung are the definitive option for many patients, yet despite the advances that have been made, there are still significant challenges in meeting the demand for viable donor grafts. Furthermore, post-operatively, the recipient faces several hurdles, including poor early outcomes like primary graft dysfunction as well as acute and chronic forms of graft rejection. In the effort to address these issues, innovations in organ engineering and treatment have been developed. This review covers efforts made to expand the donor pool including bioengineering techniques and the use of ex vivo graft perfusion. The review covers modifications and treatments which have been trialed and explores research efforts both in abdominal organs and thoracic organs. Overall, this article discusses recent innovations in machine perfusion and organ bioengineering with the aim to improve and increase the quality of donor organs.