AUTHOR=Butani Lavjay , Tancredi Daniel 

TITLE=Outcomes of Kidney Transplants From Toxoplasma-Positive Donors: An Organ Procurement and Transplant Network Database Analysis

JOURNAL=Transplant International

VOLUME=Volume 37 - 2024

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.13203

DOI=10.3389/ti.2024.13203

ISSN=1432-2277

ABSTRACT=There is a need to reconsider accepting organs from donors considered suboptimal, in the absence of data. Toxoplasma antibody positive donors (TPD) constitute one such group. The objective of our study was to compare graft survival in deceased donor renal transplant (Tx) recipients, stratified by Toxoplasma IgG status, using the Organ Procurement and Transplantation Network (OPTN) database. A log-linear event history regression model for graft failure categorized by Toxoplasma IgG status, adjusting for confounders was applied to recipients of 1 st kidney only Tx from 2018-2022. Of the 51422 Tx, 4317 (8.4%) were from TPD. Acute rejection and graft failure (5% each) were similar among groups.The crude graft failure was 7.3 failures per 100 person-years for TPD recipients compared to 6.5 failures per 100 person-years for the Toxoplasma negative group (p 0.008). The crude failure rate ratio was 1.14 with the adjusted hazard rate ratio of 1.04 (95% CI: 0.94, 1.15, p 0.39). In renal Tx recipients, TPD graft recipients have comparable survival to Tx from Toxoplasma negative recipients. While caution must still be taken and close monitoring of recipients undertaken post-Tx for surveillance of disseminated toxoplasmosis, our study suggests that patients can be successfully managed using organs from TPD.