AUTHOR=Sandiumenge Alberto , Bello Irene , Coll-Torres Elisabeth , Gomez-Brey Aroa , Franco-Jarava Clara , Miñambres Eduardo , Pérez-Redondo Marina , Mosteiro Fernando , Sánchez-Moreno Laura , Crowley Silvana , Fieira Eva , Suberviola Borja , Mazo Cristopher Alan , Agustí Alvar , Pont Teresa 

TITLE=Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients

JOURNAL=Transplant International

VOLUME=Volume 37 - 2024

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.12512

DOI=10.3389/ti.2024.12512

ISSN=1432-2277

ABSTRACT=Brain death triggers a systemic inflammatory response. Whether systemic inflammation is different in lung donors after brain-(DBD) or circulatory-death (DCD) is unknown, but this may potentially increase the incidence of primary graft dysfunction (PGD) after lung transplantation. We compared the plasma levels of interleukin (IL)-6, IL-8, IL-10 and TNF- in BDB and DCD and their respective recipients, as well as their relationship with PGD and mortality after LT. A prospective, observational, multicenter, comparative, cohort-nested study that included 40 DBD and 40 DCD lung donors matched and their respective recipients. Relevant clinical information and blood samples were collected before/during lung retrieval in donors and before/during/after (24, 48 and 72h) LT in recipients. Incidence of PGD and short-term mortality after LT was recorded. Plasma levels of all determined cytokines were numerically higher in DBD than in DCD donors and reached statistical significance for IL-6, IL-10 and IL-8.In recipients with PGD the donor's plasma levels of TNF- were higher. The postoperative mortality rate was very low and similar in both groups. DBD is associated with higher systemic inflammation than DCD donors, and higher TNF- plasma levels in donors are associated with a higher incidence of PGD.