AUTHOR=Srisuwarn Praopilad , Sutharattanapong Napun , Disthabanchong Sinee , Kantachuvesiri Surasak , Kitiyakara Chagriya , Phakdeekitcharoen Bunyong , Ingsathit Atiporn , Sumethkul Vasant 

TITLE=Incidence of De Novo Post-Transplant Malignancies in Thai Adult Kidney Transplant Recipients: A Single-Center, Population-Controlled, Retrospective Cohort Study at the Highest Volume Kidney Transplant Center in Thailand

JOURNAL=Transplant International

VOLUME=Volume 37 - 2024

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2024.11614

DOI=10.3389/ti.2024.11614

ISSN=1432-2277

ABSTRACT=Kidney transplant recipients (KTRs) are at increased risk of developing de novo posttransplant malignancies (PTMs) with regional differences in types with excessive risk compared to the general population. A single-centered, population-controlled, retrospective cohort study was conducted at a tertiary care center in Thailand among all adults undergoing their first kidney transplant from 1986 to 2018. Age-, sex-, and place of residence-standardized incidence ratio (SIR) of malignancy were obtained using Thailand's national cancer registry data as the population control. There were 2,024 KTRs [mean age, 42.4 years (SD 11.4); female, 38.6%] during 16,495 personyears at risk. Of these, 125 patients (6.2%) developed 133 de novo PTM. SIR of all PTMs was 3.85 (95%CI 3.22, 4.56), and was 3.32 (95%CI 2.73, 3.99) for solid and hematologic PTMs pooled. Urothelial malignancy had the greatest excessive risk, especially among females [SIR of female 114.7 (95%CI 66.8, 183.6); SIR of male 17.5 (95%CI 8.72, 31.2)]. The next two most common were non-Hodgkin's lymphoma and skin cancer [SIR 20.3 (95%CI 13.6, respectively]. Future studies are needed to identify the risk factors and assess the need for systematic screening among PTMs with excessive risk in KTRs.