AUTHOR=Patel Suhani S. , Lonze Bonnie E. , Chiang Teresa Po-Yu , Al Ammary Fawaz , Segev Dorry L. , Massie Allan B. 

TITLE=External Validation of Toulouse-Rangueil eGFR12 Prediction Model After Living Donor Nephrectomy

JOURNAL=Transplant International

VOLUME=Volume 36 - 2023

YEAR=2023

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.11619

DOI=10.3389/ti.2023.11619

ISSN=1432-2277

ABSTRACT=Although most living kidney donors do not experience renal complications, they face an increased longterm risk of end stage renal disease (ESRD) compared to healthy nondonors. A model to predict postdonation eGFR as a marker for risk of ESRD can aid in predonation donor evaluation and counseling.The Toulouse-Rangueil model (TRM), developed by Benoit et al., estimates postdonation 12-month eGFR based on predonation characteristics. Subsequent studies successfully externally validated the TRM in single-center cohorts in France, Portugal, and Germany. However, applicability of the TMR to donors outside of Europe is unclear. Therefore, we externally validate the TRM using national registry data from the United States. We found that the TRM systematically overestimated postdonation renal function in our cohort. Notably, overestimation was greatest for those at higher risk for postdonation ESRD including male, Black, and younger donors. We recommend that the TRM not be used for evaluation of candidates for living kidney donation in the United States. Caution may be warranted in countries outside of Europe, or with younger donor candidates and nonwhite donor candidates in Europe.