AUTHOR=Gopal Jeevan Prakash , McLean Adam , Muthusamy Anand 

TITLE=Metabolic Outcomes After Pancreas Transplant Alone From Donation After Circulatory Death Donors-The UK Transplant Registry Analysis

JOURNAL=Transplant International

VOLUME=Volume 36 - 2023

YEAR=2023

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2023.11205

DOI=10.3389/ti.2023.11205

ISSN=1432-2277

ABSTRACT=Extrapolating data from early DCD (donation after circulatory death) kidney transplantation, pancreas transplants from DCD grafts were feared to have worse metabolic outcomes. Hence, we aimed to address the question of pancreas transplant alone (PTA) from DCD donors– are our concerns justified? A UK transplant registry analysis of 185 PTA performed between 2005 and 2018 was done. All early graft losses (<3 months) were excluded to allow focus on the metabolic outcomes (HbA1c, weight gain & incidence of secondary diabetic macrovascular complications). The aim was to compare the metabolic outcomes, rejection rates (including need for steroids), patient & graft survival between DBD (Donation after brainstem death) & DCD groups. Data from 162 PTA (DBD=114 & DCD=48) were analyzed. Body mass index of the donor was less in DCD cohort (DBD=23.40 vs. DCD=22.25, P=0.006) and the rest of the baseline transplant characteristics were comparable. There were no significant differences in the HbA1c, weight gain, rejection rate, & incidence of secondary diabetic macrovascular complications post-transplant between DBD & DCD recipients. The 1-, 5-, &10-years patient and graft survival were similar in both the groups. PTA from DCD donors have equivalent metabolic outcomes and survival (patient/graft) as that of DBD donors.