AUTHOR=Meinderts Jildau R. , Prins Jelmer R. , Berger Stefan P. , De Jong Margriet F. C. 

TITLE=Follow-Up of Offspring Born to Parents With a Solid Organ Transplantation: A Systematic Review

JOURNAL=Transplant International

VOLUME=Volume 35 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10565

DOI=10.3389/ti.2022.10565

ISSN=1432-2277

ABSTRACT=Pregnancy after solid organ transplantation (SOT) has potential risks for the offspring. Most existing research focused on short-term pregnancy outcomes. Aim of this systematic review was to evaluate available data concerning longer term outcomes (>1y) of these children. A systematic literature search, following PRISMA guidelines, of PubMed and Embase was performed from the earliest date of inception through April 6th 2022. Publications on all types of (combined) SOT were eligible for inclusion. 53 articles were included. The majority assessed offspring after kidney (78% of offspring) or liver transplantation (17% of offspring). 33 studies included offspring aged >4 years and five offspring aged >18 years. One study was included on fathers with SOT. The majority of the 1664 included children after maternal SOT had normal intellectual, psychomotor and behavioral development. Although prematurity and low birth weight were commonly present, regular growth after one year of age was described. No studies reported opportunistic or chronic infections or abnormal response to vaccinations. In general, pregnancy after SOT appears to have reassuring longer term outcomes in the offspring. However, existing information is predominantly limited to studies with young children. Longer prospective studies with follow-up into adulthood of these children are warranted.