AUTHOR=Ferrer-Fàbrega Joana , Folch-Puy Emma , Lozano Juan José , Ventura-Aguiar Pedro , Cárdenas Gabriel , Paredes David , García-Criado Ángeles , Bombí Josep Antoni , García-Pérez Rocío , López-Boado Miguel Ángel , Rull Ramón , Esmatjes Enric , Ricart Maria José , Diekmann Fritz , Fondevila Constantino , Fernández-Cruz Laureano , Fuster Josep , García-Valdecasas Juan Carlos 

TITLE=Current Trends in Organ Preservation Solutions for Pancreas Transplantation: A Single-Center Retrospective Study

JOURNAL=Transplant International

VOLUME=Volume 35 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10419

DOI=10.3389/ti.2022.10419

ISSN=1432-2277

ABSTRACT=Due to the high vulnerability of the pancreas to ischemia-reperfusion injury, choices regarding preservation solution markedly affect pancreas transplant success. A retrospective single-center analysis of 380 pancreas transplants (2000-2019) was performed to correlate current preservation solutions with transplant outcomes. Early graft failure requiring transplantectomy within 30 days post-transplant occurred in 7.5% for University of Wisconsin (UW) group (n=267), 10.8% of Celsior (CS) group (n=83), 28.5% of Histidine-Tryptophan-Ketoglutarate (HTK) group (n=7), and none for Institut Georges Lopez-1 (IGL-1) group (n=23). The most common causes of technical failures in this cohort included abdominal hemorrhage (8.4%); graft pancreatitis (3.7%); fluid collections (2.6%); intestinal complications (6.6%); and vascular thrombosis (20.5%). Although IGL-1 solution provided lower surgical complication rates, no significant differences were found between studied groups.  Nevertheless, HTK solution was associated with elevated pancreatitis rates. The best graft survival was achieved at 1 year using UW and IGL-1, and at 3 and 5 years using IGL-1 (P = 0.017). There were no significant differences in patient survival after a median follow-up of 118.4 months. In this setting therefore, IGL-1 solution appears promising for perfusion and organ preservation in clinical pancreas transplantation, compared to other commonly used solutions.