AUTHOR=Chang Alex , Schaubel Douglas E. , Chen Melissa , Abt Peter L. , Bittermann Therese 

TITLE=Trends and Outcomes of Hypothermic Machine Perfusion Preservation of Kidney Allografts in Simultaneous Liver and Kidney Transplantation in the United States

JOURNAL=Transplant International

VOLUME=Volume 35 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10345

DOI=10.3389/ti.2022.10345

ISSN=1432-2277

ABSTRACT=Optimal kidney graft outcomes after simultaneous liver-kidney (SLK) transplant may be threatened by the increased cold ischemia time and hemodynamic perturbations of dual organ transplantation. Hypothermic machine perfusion (MP) of kidney allografts may mitigate these effects. We analyzed U.S. trends and renal outcomes of hypothermic non-oxygenated MP vs static cold storage (CS) of kidney grafts from 6,689 SLK transplants performed between 2005-2020 using the United Network for Organ Sharing database. Outcomes included delayed graft function (DGF), primary non-function (PNF), and kidney graft survival (GS). Overall, 17.2% of kidney allografts were placed on MP. Kidney cold ischemia time was longer in the MP group (median 12.8 vs 10.0 hours; p<0.001). Nationally, MP utilization in SLK increased from <3% in 2005 to >25% by 2019.  Center preference was the primary determinant of whether a graft underwent MP vs CS (intraclass correlation coefficient 65.0%). MP reduced DGF (adjusted OR 0.74; p=0.008), but not PNF (p=0.637). Improved GS with MP was only observed with Kidney Donor Profile Index <20% (HR 0.71; p=0.030). Kidney MP has increased significantly in SLK in the U.S. in a heterogeneous manner and with variable short-term benefits. Additional studies are needed to determine the ideal utilization for MP in SLK.