AUTHOR=Tandukar Srijan , Wu Christine , Hariharan Sundaram , Puttarajappa Chethan 

TITLE=Impact of Size Matching Based on Donor-Recipient Height on Kidney Transplant Outcomes

JOURNAL=Transplant International

VOLUME=Volume 35 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10253

DOI=10.3389/ti.2022.10253

ISSN=1432-2277

ABSTRACT=Transplantation of kidneys from shorter donors into taller recipients may lead to suboptimal allograft survival. The effect of discrepancy in donor and recipient heights (Height) on long term transplant outcomes is not known. Adult patients >18 years undergoing living or deceased donor (LD or DD) kidney transplant alone from donors >18 years between 2000 and 2016 in United States were included in this observational study. The cohort was divided into three groups based on Height of 5 inches as (i) RecipientDonor [DD: 21,741, LD: 18,753]. Univariate analysis showed higher risk of DCGL and mortality in both DD and LD (p<0.001 for both). The absolute difference in graft and patient survival between the two extremes of Height was 5.7% and 5.7% for DD, and 0.4% and 1.4% for LD. On multivariate analysis, the HR of DCGL for RecipientDonor was 0.95 (p=0.05) and 1.07 (p=0.01) in DD and 0.98 (p=0.55) and 1.14 (p<0.001) in LD. Similarly, the corresponding HR of mortality were 0.97 (p=0.07) and 1.07 (p=0.003) for DD and 1.01 (p<0.001) and 1.05 (p=0.13) for LD. For DGF, the HR were 1.04 (p=0.1) and 1.01 (p=0.7) for DD and 1.07 (p=0.45) and 0.89 (p=0.13) for LD. Height mismatch between the donor and recipient influences kidney transplant outcomes.