AUTHOR=Lee Chung-Ying , Wu Mei-Yi , Chan Hsiu-Chen , Chen Tzu-Ting , Hsu Le-Yin , Wu Mai-Szu , Cherng Yih-Giun 

TITLE=The Influence of Diabetes Mellitus on the Risks of End-Stage Kidney Disease and Mortality After Liver Transplantation

JOURNAL=Transplant International

VOLUME=Volume 35 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/transplant-international/articles/10.3389/ti.2022.10023

DOI=10.3389/ti.2022.10023

ISSN=1432-2277

ABSTRACT=This retrospective study aimed to investigate the effect of diabetes mellitus (DM) on the risks of end-stage kidney disease (ESKD) and post-LT mortality. Using data from the National Health Insurance Research Database, Taiwan, 3,489 patients who received a LT between January 1, 2005, and December 31, 2015, were enrolled in this study and divided into the pre-existing DM, post-LT DM (PLTDM), and without DM groups. All subjects were followed up from one year after LT to the index date for ESKD, and the occurrence of death, or until December 31, 2016. Of the 3,489 patients with LT, 1,016 had pre-existing DM, 215 had PLTDM, and 2,258 had no DM pre- or post-LT. The adjusted HRs of ESKD were 1.19 1.77 (95% Confidence Interval [CI], 0.78–3.99) and 2.61 (95% CI, 1.63–4.18) for PLTDM group and pre-existing DM group compared to without DM group, respectively. For the risk of death, the adjusted HRs were 1.05 (95% CI, 0.72–1.55) and 1.28 (95% CI, 1.04–1.59) for PLTDM group and pre-existing DM group compared to those without DM group, respectively. The sensitivity analysis for the risk of ESKD and death also revealed the consistent result. Pre-existing DM has significant increase the risk of post-LT ESKD and mortality. The role of PLTDM should be explored to explain postoperative morbidity and mortality.