AUTHOR=Svotin Artem A. , Taldaev Amir , Nikitin Ilya D. , Korochkina Maria D. , Terekhov Roman P. , Selivanova Irina A. 

TITLE=Insights in wound healing properties of water-soluble composition of dihydroquercetin and L-lysine

JOURNAL=Journal of Pharmacy & Pharmaceutical Sciences

VOLUME=Volume 28 - 2025

YEAR=2025

URL=https://www.frontierspartnerships.org/journals/journal-of-pharmacy-pharmaceutical-sciences/articles/10.3389/jpps.2025.13831

DOI=10.3389/jpps.2025.13831

ISSN=1482-1826

ABSTRACT=This study focuses on the implementation of a composition of the natural flavonoid dihydroquercetin (DHQ) with L-lysine in treatment of thermal burns. The wound healing activity of DHQ is well-known. The addition of amino acid in the composition increases the flavonoids' water solubility, providing an opportunity to develop spray dosage form. The research involved 60 male Wistar rats divided into five treatment groups. Sea buck oil served as a positive control. On day 14, the composition treatment group showed significant advancement in wound healing, being 9.6±2.0% ahead of the other groups in absolute values. By day 35, treatment with the composition resulted in a significant decrease of relative wound area to 1.9±0.9%, while in the negative and positive control groups it was 10.7±7.8% and 8.4±4.9%, respectively. At the same time, the epidermal and dermal layers are clearly distinguished on composition treatment according to histological analysis. A large number of collagen fibers is clearly visible, and the active keloid scar formation process is noted. An additive effect from the combined use of DHQ and L-lysine was observed (F = 0.21, p = 0.649). A natural next step is to develop the dosage form for DHQ-L-lysine composition.