AUTHOR=Meng Fanda , Qiao Xinyu , Xin Chenglong , Ju Xiaoli , He Meilin 

TITLE=Recent progress of polymeric microneedle-assisted long-acting transdermal drug delivery

JOURNAL=Journal of Pharmacy & Pharmaceutical Sciences

VOLUME=Volume 27 - 2024

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/journal-of-pharmacy-pharmaceutical-sciences/articles/10.3389/jpps.2024.12434

DOI=10.3389/jpps.2024.12434

ISSN=1482-1826

ABSTRACT=Microneedles (MNs)-assisted drug delivery technology has gained more and more attention in recent 20 years. Its advantages of minimally invasive and self-management could allow this technology to be an alternative of hypodermic needles. MNs can penetrate the stratum corneum and deliver active ingredients to the body through the dermal tissue in a controlled and sustained release. Long-acting polymeric MNs can reduce the administration frequency to improve patient compliance and therapeutic outcomes, especially in the management of chronic diseases. In addition, long-acting MNs could avoid the gastrointestinal reaction and reduce side effects, which has potential value for clinical application. In this paper, the advances of design strategies and applications of long-acting polymeric MNs were reviewed. Finally, we discussed the challenges in scale manufacture and regulations of polymeric MNs system. These will the challenges of accelerateing the effective clinical translation of MNs product.