AUTHOR=Sugiyama Akiko , Fukushima Takehito , Okabe Koki , Shimada Kiyotaka , Kojima Kaoru , Shigeoka Yuko , Honjo Satoshi , Kishikawa Reiko 

TITLE=Effective and safe provocation test for wheat-dependent exercise-induced anaphylaxis (WDEIA) in adults results of testing on 33 cases

JOURNAL=Journal of Cutaneous Immunology and Allergy

VOLUME=Volume 7 - 2024

YEAR=2024

URL=https://www.frontierspartnerships.org/journals/journal-of-cutaneous-immunology-and-allergy/articles/10.3389/jcia.2024.12896

DOI=10.3389/jcia.2024.12896

ISSN=2574-4593

ABSTRACT=BACKGROUND: Wheat-dependent exercise-induced anaphylaxis (WDEIA) is induced not by the intake of wheat-based food alone, but by the combination of exercise stress and such intake. Provocation tests have been reported to be useful for the diagnosis of this condition, but they are not always accurate. Furthermore, provocation tests are associated with the risk of anaphylactic shock, so safer testing is required.SUBJECTS AND METHODS: Thirty-three patients (mean age 35.5 ± 16.0 years) who underwent provocation tests from April 2019 to July 2023 were included in this study. We CONCLUSION: Wheat-specific IgE as well as gluten and ω-5 gliadin antibody titers are associated with WDEIA symptom severity. Exercise loading with a target heart rate of 70%-90% of that calculated by the Karvonen formula is safe and useful for diagnosis this condition.