AUTHOR=Calderon Samuel Josias Bizerra , Lyra Humberto Fenner , Onzi Tiago Rafael , Kremer Gilberto , Miranda Fernando Ferraz de , de Oliveira Filho Getúlio Rodrigues TITLE=Quality of Life and Post-Operative Pain Following Laparoscopic Inguinal Hernia Repair With Self-Fixating Mesh: a Prospective Observational Study JOURNAL=Journal of Abdominal Wall Surgery VOLUME=Volume 4 - 2025 YEAR=2025 URL=https://www.frontierspartnerships.org/journals/journal-of-abdominal-wall-surgery/articles/10.3389/jaws.2025.15203 DOI=10.3389/jaws.2025.15203 ISSN=2813-2092 ABSTRACT=BackgroundLaparoscopic inguinal hernia repair using self-fixating mesh has been associated with advantages such as reduced post-operative pain and fewer complications. However, chronic pain and quality-of-life outcomes remain concerns. Objective: To evaluate post-operative quality of life and pain following transabdominal preperitoneal (TAPP) hernia repair using self-fixating mesh.MethodsThis prospective observational study included 90 patients undergoing TAPP hernia repair in a institution in Brazil between 2023 and 2025. Quality of life was assessed using the EuraHS-QoL questionnaire at baseline, 1, 3, and 6 months post-operatively. Pain was measured using a numeric rating scale. Descriptive and inferential statistical analyses, including linear mixed models, were applied.ResultsMost patients were male (94.4%) with a mean age of 57.9 years. EuraHS-QoL scores improved significantly at 3 and 6 months post-operatively compared to baseline (p < 0.001). No significant improvement was noted at 1 month. Pain and cosmetic domain scores improved early, while the restriction domain showed delayed improvement. Chronic pain rates at 3 months were among the lowest reported in the literature.ConclusionTAPP hernia repair with self-fixating mesh resulted in significant quality-of-life improvement beginning at 3 months post-operatively. The self-fixating mesh technique demonstrated favorable outcomes, including low chronic pain incidence.