AUTHOR=Pan Tinghong , Wang Hui , Wang Shuai , Liu Feng 

TITLE=Long Non-Coding RNA LINC01929 Facilitates Cell Proliferation and Metastasis as a Competing Endogenous RNA Against MicroRNA miR-1179 in Non-Small Cell Lung Carcinoma

JOURNAL=British Journal of Biomedical Science

VOLUME=Volume 79 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/british-journal-of-biomedical-science/articles/10.3389/bjbs.2022.10598

DOI=10.3389/bjbs.2022.10598

ISSN=2474-0896

ABSTRACT=Background: Non-small cell lung carcinoma (NSCLC) constitutes most lung cancer and may lead to a poor prognosis. This study was to explore the role of LINC01929 in NSCLC, both the clinical prognostic significance and the mechanism of its influence on cells. 
Methods: LINC01929 levels in 143 pairs of NSCLC tissues and non-cancerous tissues were detected by RT-qPCR. Kaplan-Meier curves and multivariate Cox regression assays were generated for evaluating the prognostic values of LINC01929. To evaluate the cellular function, XTT assay and transwell invasion assay were performed. 
Results: LINC01929 was up-regulated in NSCLC tissues compared with normal tissues. A positive correlation was observed between LINC01929 expression level and tumor T or N stage. Patients with higher LINC01929 represented shorter overall survival. Compared with other factors, high LINC01929 expression was significantly associated with poor survival. miR-1179 was a target miRNA of LINC01929. Inhibited expression of LINC01929 significantly reduced the proliferation, migration, and invasion of NSCLC cells by targeting miR-1179. 
Conclusion: This study supported the promising trend of LINC01929 as a prognostic factor and therapy target for NSCLC.