AUTHOR=Li Dancen , Pan Jingjun 

TITLE=Diagnostic and Prognostic Value Analysis of miR-206 in Asymptomatic Carotid Artery Stenosis

JOURNAL=British Journal of Biomedical Science

VOLUME=Volume 79 - 2022

YEAR=2022

URL=https://www.frontierspartnerships.org/journals/british-journal-of-biomedical-science/articles/10.3389/bjbs.2022.10592

DOI=10.3389/bjbs.2022.10592

ISSN=2474-0896

ABSTRACT=Aim: To investigate the expression level of miR-206 in serum of patients with asymptomatic carotid artery stenosis (CAS) and estimate the meaning of miR-206 in the diagnosis and prognosis of asymptomatic CAS.
Methods: A total of 206 individuals enrolled in this study, including 105 CAS patients and 101 controls. RT-qPCR technology was applied to measure the relative level of miR-206, and Pearson correlation coefficient was performed to analyze the relationship between carotid artery stenosis degree and miR-206 level. ROC curve was drawn to assess the diagnostic value of miR-206 in asymptomatic CAS. The 5-year prognosis of asymptomatic CAS patients was tested using multivariate Cox regression analysis and Kaplan-Meier survival curve. 
Results: MiR-206 expression was reduced in asymptomatic CAS patients. The AUC of ROC curve of miR-206 was 0.939, with the sensitivity of 86.70% and the specificity of 86.14%. The degree of CAS gradually increased with the decrease of miR-206 level. 17 patients in the low miR-206 expression group developed CIEs, and 3 patients in the high miR-206 expression group developed CIEs during the 5-year follow-up. miR-206 and the degree of CAS were the  independent factors for the occurrence of CIEs within 5 years in asymptomatic CAS patients.
Conclusions: Serum miR-206 has high diagnostic accuracy for asymptomatic CAS and has predictive value for the incidence of CIEs in patients within 5 years.