AUTHOR=Chen Grace , Rahman Shafiqur , Lutfy Kabirullah TITLE=E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs JOURNAL=Advances in Drug and Alcohol Research VOLUME=Volume 3 - 2023 YEAR=2023 URL=https://www.frontierspartnerships.org/journals/advances-in-drug-and-alcohol-research/articles/10.3389/adar.2023.11345 DOI=10.3389/adar.2023.11345 ISSN=2674-0001 ABSTRACT=E-cigarettes are devices that allow to inhale nicotine in a vapor and primarily marketed as a means of smoking cessation and a less harmful replacement for traditional cigarette smoking. However, further research is needed to determine if vaping nicotine via e-cigarettes can be effective. Nicotine has been considered as a gateway drug to alcohol and other addictive drugs and e-cigarettes containing nicotine may have the same effects. Previous reports have shown that e-cigarette use may open the gate for the use of other drugs including conventional cigarettes, cannabis, opioids, etc. E-cigarettes can also be used as a device to self-administer cocaine and other addictive agents. This review aims to briefly describe the e-cigarettes and its different generation and their co-use with other addictive drugs.