AUTHOR=Džubara Jozef , Štibrániová Iveta , Maliterná Michaela , Levina Daria Romanivna , Žilka Tomáš , Baráthová Monika , Belvončíková Petra , Jakubíková Jana , Kabát Peter 

TITLE=First evidence of murid gammaherpesvirus 4 (MHV-68) virus in the blood of oncological patients

JOURNAL=Acta Virologica

VOLUME=Volume 69 - 2025

YEAR=2025

URL=https://www.frontierspartnerships.org/journals/acta-virologica/articles/10.3389/av.2025.14168

DOI=10.3389/av.2025.14168

ISSN=1336-2305

ABSTRACT=Murid gammaherpesvirus 4 (prototype strain MHV-68) is a natural pathogen of murid rodents that is able to transform lymphocytes and induce lymphoproliferative diseases and tumor transformation in their host cells. Considering that this virus can infect and multiply in various human cell lines, we think it could also play an important role in the pathogenesis of some human types of cancer. We investigated and confirmed the presence of the replication and transcription activator rta (ORF 50) from MHV-68 virus in four peripheral blood samples from patients with lymphomas and gliomas.