AUTHOR=Cambou Ludivine, Millet Clémentine, Terrier Nicolas, Malvezzi Paolo, Timsit Marc-Olivier, Anglicheau Dany, Badet Lionel, Morelon Emmanuel, Prudhomme Thomas, Kamar Nassim, Lejay Anne, Perrin Peggy, Uro-Coste Charlotte, Pereira Bruno, Heng Anne Elisabeth, Garrouste Cyril, Guy Laurent, Aniort Julien, Atenza Alba, Bisbard Xavier, Buron Fanny, Ceruti Florian, Charbonnel Cyril, Greze Clarisse, Jouve Thomas, Legendre Christophe, Levy Stephan, Matillon Xavier, Ohlmann Sophie, Philipponnet Carole, Ravel Anne, Rostaing Lionel, Salusto Frederico, Vedrine Nicolas TITLE=Management and Outcome After Early Renal Transplant Vein Thrombosis: A French Multicentre Observational Study of Real-Life Practice Over 24 Years JOURNAL=Transplant International VOLUME=36 YEAR=2023 URL=https://www.frontierspartnerships.org/articles/10.3389/ti.2023.10556 DOI=10.3389/ti.2023.10556 ISSN=1432-2277 ABSTRACT=Early (<14 days) renal transplant vein thrombosis posttransplant (eRVTPT) is a rare but threatening complication. We aimed to assess eRVTPT management and the rate of functional renal transplantation. Of 11,172 adult patients who had undergone transplantation between 01/1997 and 12/2020 at 6 French centres, we identified 176 patients with eRVTPT (1.6%): 16 intraoperative (Group 1, G1) and 160 postoperative (Group 2, G2). All but one patient received surgical management. Patients in group G2 had at least one imaging test for diagnostic confirmation (N = 157, 98%). During the operative management of the G2 group, transplantectomy for graft necrosis was performed immediately in 59.1% of cases. In both groups, either of two techniques was preferred, namely, thrombectomy by renal venotomy or thrombectomy + venous anastomosis repair, with no difference in the functional graft rate (FGR) at hospital discharge (p = NS). The FGR was 62.5% in G1 and 8.1% in G2 (p < 0.001). Numerous complications occurred during the initial hospitalization: 38 patients had a postoperative infection (21.6%), 5 experienced haemorrhagic shock (2.8%), 29 exhibited a haematoma (16.5%), and 97 (55.1%) received a blood transfusion. Five patients died (2.8%). Our study confirms the very poor prognosis of early renal graft venous thrombosis.